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zodiaccity:

Big shoutout to all the Leos celebrating a birthday from July 23 - Aug 23.

zodiaccity:

Big shoutout to all the Leos celebrating a birthday from July 23 - Aug 23.

15 hours ago 1,408 notes Via zodiaccity
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gif-lab:

Guillermo Ochoa vs Brazil (x)

15 hours ago 5,527 notes By gif-lab Via giovani-dos-santos
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"I hope you support your team always not only when we are winning but when we are losing, because we are not only winning together but losing together."

- Louis van Gaal (via iloveunited)

15 hours ago 39 notes Via iloveunited
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neurosciencestuff:

Schizophrenia’s genetic skyline rising

The largest genomic dragnet of any psychiatric disorder to date has unmasked 108 chromosomal sites harboring inherited variations in the genetic code linked to schizophrenia, 83 of which had not been previously reported. By contrast, the “skyline” of such suspect variants associated with the disorder contained only 5 significant peaks in 2011. By combining data from all available schizophrenia genetic samples, researchers supported by the National Institutes of Health powered the search for clues to the molecular basis of the disorder to a new level.

“While the suspect variation identified so far only explains only about 3.5 percent of the risk for schizophrenia, these results warrant exploring whether using such data to calculate an individual’s risk for developing the disorder might someday be useful in screening for preventive interventions,” explained Thomas R. Insel, M.D., director of the NIH’s National Institute of Mental Health, one funder of the study. “Even based on these early predictors, people who score in the top 10 percent of risk may be up to 20-fold more prone to developing schizophrenia.”

The newfound genomic signals are not simply random sites of variation, say the researchers. They converge around pathways underlying the workings of processes involved in the disorder, such as communication between brain cells, learning and memory, cellular ion channels, immune function and a key medication target.

The Schizophrenia Working Group of the Psychiatric Genomic Consortium (PGC) reports on its genome-wide analysis of nearly 37,000 cases and more than 113,000 controls in the journal Nature, July 21, 2014. The NIMH-supported PGC represents more than 500 investigators at more than 80 research institutions in 25 countries.

Prior to the new study, schizophrenia genome-wide studies had identified only about 30 common gene variants associated with the disorder. Sample sizes in these studies were individually too small to detect many of the subtle effects on risk exerted by such widely shared versions of genes. The PGC investigators sought to maximize statistical power by re-analyzing not just published results, but all available raw data, published and unpublished. Their findings of 108 illness-associated genomic locations were winnowed from an initial pool of about 9.5 million variants.

A comparison of the combined study data with findings in an independent sample of cases and controls suggest that considerably more such associations of this type are likely to be uncovered with larger sample sizes, say the researchers.

There was an association confirmed with variation in the gene that codes for a receptor for the brain chemical messenger dopamine, which is known to be the target for antipsychotic medications used to treat schizophrenia. Yet evidence from the study supports the view that most variants associated with schizophrenia appear to exert their effects via the turning on and off of genes rather than through coding for proteins.

The study found a notable overlap between protein-related functions of some linked common variants and rare variants associated with schizophrenia in other studies. These included genes involved in communication between neurons via the chemical messenger glutamate, learning and memory, and the machinery controlling the influx of calcium into cells.

“The overlap strongly suggests that common and rare variant studies are complementary rather than antagonistic, and that mechanistic studies driven by rare genetic variation will be informative for schizophrenia,” say the researchers.

Among the strongest associations detected, as in in previous genome-wide genetic studies, was for variation in tissues involved in immune system function. Although the significance of this connection for the illness process remains a mystery, epidemiologic evidence has long hinted at possible immune system involvement in schizophrenia.

Findings confirm that it’s possible to develop risk profile scores based on schizophrenia-associated variants that may be useful in research – but for now aren’t ready to be used clinically as a predictive test, say the researchers.

They also note that the associated variations detected in the study may not themselves be the source of risk for schizophrenia. Rather, they may be signals indicating the presence of disease-causing variation nearby in a chromosomal region.

Researchers are following up with studies designed to pinpoint the specific sequences and genes that confer risk. The PGC is also typing genes in hundreds of thousands of people worldwide to enlarge the sample size, in hopes of detecting more genetic variation associated with mental disorders. Successful integration of data from several GWAS studies suggests that this approach would likely be transferrable to similar studies of other disorders, say the researchers.

“These results underscore that genetic programming affects the brain in tiny, incremental ways that can increase the risk for developing schizophrenia,” said Thomas Lehner, Ph.D., chief of NIMH’s Genomics Research Branch. “They also validate the strategy of examining both common and rare variation to understand this complex disorder.”

15 hours ago 159 notes Via neurosciencestuff
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iloveunited:

"When I first turned up everyone was telling me how big the club was but you don’t realise how big it is until you come away on a pre-season tour. It’s crazy. Personally, I think Manchester United is the biggest club and it will push me to do my best. I signed a contract here because I know what the club is capable of. I know I will improve at the club."
- Luke Shaw

iloveunited:

"When I first turned up everyone was telling me how big the club was but you don’t realise how big it is until you come away on a pre-season tour. It’s crazy. Personally, I think Manchester United is the biggest club and it will push me to do my best. I signed a contract here because I know what the club is capable of. I know I will improve at the club."

Luke Shaw

15 hours ago 15 notes Via iloveunited
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iloveunited:

David Beckham visited Manchester United in Los Angeles.

15 hours ago 54 notes Via iloveunited
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so-pleasantly-strange:

acid-anarchism:

ny007ny:

Instead of killing an unwanted  tree , this machine makes it possible to move it to a new place instead.

woah

#HOW FUCKING COOL IS THIS THING#IT’S ALL LIKE#’GGRRRAAAAAAWWWWWWWW’#AND THE TREE IS ALL LIKE#’WHOOP!’#AND IT’S ALL LIKE SHIT YEAH GOT A TREE#this could also be used for murder.
15 hours ago 18,150 notes By ny007ny Via aholeintheground
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watchtheskytonight:

little-bit-fancy:

Today I came across a wi-fi connection called ‘Hogwarts’
I decided I would hack my first wi-fi
I put in ‘alohomora’ 
It worked 

bless you

15 hours ago 73,930 notes By johngreenisokay Via norsedemigod
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15 hours ago 17,883 notes By pleatedjeans Via thats-so-meme
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plaidandredlipstick:

the reason male comic book fans work themselves into a frenzied rage over “fake geek girls" is because they think they can’t get a girlfriend because of their love for comic books (a.k.a nerdiness). if they accept that geek girls genuinely love comic books, then they’re left with the cold harsh reality that it’s not their nerdiness that makes them unattractive to women, but the fact that they are misogynistic condescending dickbags who need to be avoided AT ALL COSTS

15 hours ago 103,948 notes By plaidandredlipstick Via lilamedusa
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divineirony:

The truth has nothing to fear from inquiry. Be wary of anyone who would discourage questions.

divineirony:

The truth has nothing to fear from inquiry. Be wary of anyone who would discourage questions.

15 hours ago 563 notes By divineirony Via wildcat2030
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I’d probably do the same

15 hours ago 11,462 notes By lietometonight Via norsedemigod
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unfollovving:

seqments:

paleth0ughts:

lnternetexplorers:

where’s your god now

imagine o m g

they’re here for the hot choclety

they can have it

unfollovving:

seqments:

paleth0ughts:

lnternetexplorers:

where’s your god now

imagine o m g

they’re here for the hot choclety

they can have it

16 hours ago 170,369 notes Via norsedemigod
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psych2go:

For more posts like these, go visit psych2go
Psych2go features various psychological findings and myths. In the future, psych2go attempts to include sources to posts for the for the purpose of generating discussions and commentaries. This will give readers a chance to critically examine psychology. 
Fact submitted by: speckledwillow

psych2go:

For more posts like these, go visit psych2go

Psych2go features various psychological findings and myths. In the future, psych2go attempts to include sources to posts for the for the purpose of generating discussions and commentaries. This will give readers a chance to critically examine psychology.

Fact submitted by: speckledwillow

16 hours ago 5,029 notes By psych2go Via psych-facts
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joshpeck:

thesylverlining:

what happened in roughly 1870 though
why was there temporary internet
with a few people searching for pokemon?

joshpeck:

thesylverlining:

what happened in roughly 1870 though

why was there temporary internet

with a few people searching for pokemon?

image

16 hours ago 103,839 notes By neilcicierega Via thats-so-meme
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